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The main causes of methylation include: Genetic mutations such as in MTHFR and other associated gene mutations MTHFR Gene mutations C667T & A1298C Nutritional problems Stress (Mental & physical) Environmental chemicals & toxins Heavy metal toxicity Medications (antacids, methotrexate, metformin, nitrous oxides, antiseptics) Reduced hydrochloric acids for digestion Aging (as we age methylation can reduce) Diet Alcohol The importance of homocysteine in methylation One the more important methylation processes is called the homocysteine cycle, this process is vital in keeping us healthy and so having homocysteine out of balance can mean big problems, this is because homocysteine needs to be converted to SAMe (at the top) and glutathione (at the bottom) as per the diagram below

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Supplements for Glutathione Enhancement Various supplements have gained attention for their potential to increase glutathione levels

Uric acid may inhibit endothelial function by inhibition of nitric oxide-function under conditions of oxidative stress